Improving Safety of Glucose Control in Intensive Care using Virtual Patients and Simulated Clinical Trials

Fisk, Liam M.; Le Compte, Aaron J.; Shaw, Geoffrey M.; Chase, J. Geoffrey

doi:https://doi.org/10.1260/2040-2295.3.3.415

Journal of Healthcare Engineering

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Research Article | Open Access

Volume 3 | Article ID 249039 | https://doi.org/10.1260/2040-2295.3.3.415

Improving Safety of Glucose Control in Intensive Care using Virtual Patients and Simulated Clinical Trials

Liam M. Fisk,¹Aaron J. Le Compte,¹Geoffrey M. Shaw,²and J. Geoffrey Chase¹

Received01 Nov 2011

Accepted01 Apr 2012

Abstract

Despite the potential clinical benefits of normalizing blood glucose in critically ill patients, the risk of hypoglycemia is a major barrier to widespread clinical adoption of accurate glycemic control. To compare five glucose control protocols, a validated insulin-glucose system model was employed to perform simulated clinical trials. STAR, SPRINT, UNC, Yale and Glucontrol protocols were assessed over a medical-surgical intensive care unit patient cohort. Results were interpreted separately for patients with low to high sensitivity to insulin, and low to high variability in metabolic state. STAR and SPRINT provided good glucose control with risk of severe hypoglycemia less than 0.05% across all patient groups. UNC also achieved good control for patients with low and medium levels of insulin sensitivity (SI), but risk of severe hypoglycemia was raised for patients with high SI. Glucontrol showed degradation of performance for patients with high metabolic variability.

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Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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