主催: 公益社団法人日本薬理学会
会議名: 第95回日本薬理学会年会
回次: 95
開催地: Fukuoka
開催日: 2022/03/07 - 2022/03/09
PRAF3, which is the PRA1 (prenylated Rab acceptor 1) superfamily member, plays crucial roles in membrane traffic as a GDI displacement factor via physical interaction with a variety of Rab proteins, as well as in the modulation of antioxidant glutathione through its interaction with EAAC1 (SLC1A1). It is known that the overexpression of PRAF3 induces the toxicity of the host cell, however, the factors capable of cancelling the cytotoxicity remained unknown. Our findings demonstrate that Rab1a can protect from the toxicity of PRAF3-overexpressed human cells. Cytoprotective effects of Rab1a protein could further suggest that PRAF3 and Rab1a are closely related to each other physiologically and genetically.