The anti-secretory and antiulcerogenic activities of a substance, which was a glycopeptide (abbreviated as GGP) and extracted from the mucosa of the third stomach of the finback whale (Balaenoptera physalus L.), were studied in detail.
GGP was shown to have a dose-dependent anti-secretory effect on gastric secretion in the Shay's rats with ligated pylorus with intravenous doses of 0.01-2.0 mg/kg.
GGP showed a significant suppressing effect on gastric secretion induced by histamine, acetylcholine and tetragastrin in the Schild rats, and also showed the similar effect on histamine- or tetragastrin-induced secretion in the Heidenhain pouch dogs.
Not only GGP showed the significant antiulcerogenic activities against the Shay rat ulcers and such experimental peptic ulcers as serotonin, histamine and stress ones, but also is exhibited a definite curative effect on the ulcer induced by acetic acid injection.
GGP may induce the anti-secretory effect through direct or indirect inhibition of activity of parietal cells, and the antiulcerogenic effect of GGP may be produced through antisecretory effect.