Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Myat Nyan; Daisuke Sato; Mitsumasa Oda; Tetsu Machida; Hiroshi Kobayashi; Takahiro Nakamura; Shohei Kasugai

doi:10.1254/jphs.SC0070184

Short Communications

Bone Formation With the Combination of Simvastatin and Calcium Sulfate in Critical-Sized Rat Calvarial Defect

Myat Nyan, Daisuke Sato, Mitsumasa Oda, Tetsu Machida, Hiroshi Kobayashi, Takahiro Nakamura, Shohei Kasugai

Author information

Myat Nyan
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan
Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Japan
Daisuke Sato
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan
Mitsumasa Oda
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan
Tetsu Machida
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan
Hiroshi Kobayashi
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan
Takahiro Nakamura
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan
Shohei Kasugai
Oral Implantology and Regenerative Dental Medicine, Tokyo Medical and Dental University, Japan
Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Japan

Keywords: simvastatin, calcium sulfate, bone formation

JOURNAL FREE ACCESS

2007 Volume 104 Issue 4 Pages 384-386

DOI https://doi.org/10.1254/jphs.SC0070184

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Abstract

Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response.

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