JAPANESE CIRCULATION JOURNAL
Online ISSN : 1347-4839
Print ISSN : 0047-1828
ISSN-L : 0047-1828
Experimental Study
Effect of Intraluminal Pressure on the Intimal Thickening in Injured Rabbit Carotid Arteries in an Organ-Culture System
Hisanori Horiuchi, Masayuki Yokode, Kenji Ishii, Mikimaro Cho, Seijiro Hara, Atsushi Sakai, Kazuo Kanai, Toyohiro Tsukada, Toru Kita
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Keywords: Intimal thickening, Injured artery, Hypertension, Stretching, Organ culture
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1997 Volume 61 Issue 8 Pages 704-708

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Abstract

We developed an organ culture system in order to examine the effect of intraluminal pressure on intimal thickening in injured arteries. After endothelial denudation, an excised rabbit common carotid artery was incubated at 37°C in a glass bottle perfused with Dulbecco's modified Eagle medium containing 10% fetal calf serum at a constant flow rate of 6 ml/h at various static pressure of 60, 95, 130, 165, or 200 cmH2O. Intimal thickening, which consisted of smooth muscle cells and extracellular matrix, increased in a time- and pressure-dependent manner up to 130 cmH2O. Excessive pressures (165 and 200 cmH2O), however, caused necrosis in the media. These results suggest that a rise in intraluminal pressure accelerates intimal thickening in injured arteries. (Jpn Circ J 1997; 61: 704 - 708)

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© 1997 THE JAPANESE CIRCULATION SOCIETY
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The Nippon Journal of Clinical Angio-Cardiology

Japanese Circulation Journal

Successor

Circulation Journal

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