Characterization of the Antiplatelet Effect of Aspirin at Enrollment and After 2-Year Follow-up in a Real Clinical Setting in Japan

Tomoyuki Ikeda; Ryoji Taniguchi; Shin Watanabe; Mitsunori Kawato; Hirokazu Kondo; Ryutaro Shirakawa; Keiichiro Yamane; Masanao Toma; Toshihiro Tamura; Kanako Takahashi; Haruyo Watanabe; Yuka Yoshikawa; Arata Tabuchi; Toru Kita; Takeshi Kimura; Hisanori Horiuchi

doi:10.1253/circj.CJ-09-0927

Vascular Medicine

Characterization of the Antiplatelet Effect of Aspirin at Enrollment and After 2-Year Follow-up in a Real Clinical Setting in Japan

Tomoyuki Ikeda, Ryoji Taniguchi, Shin Watanabe, Mitsunori Kawato, Hirokazu Kondo, Ryutaro Shirakawa, Keiichiro Yamane, Masanao Toma, Toshihiro Tamura, Kanako Takahashi, Haruyo Watanabe, Yuka Yoshikawa, Arata Tabuchi, Toru Kita, Takeshi Kimura, Hisanori Horiuchi

Author information

Tomoyuki Ikeda
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Ryoji Taniguchi
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Shin Watanabe
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Mitsunori Kawato
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Hirokazu Kondo
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Ryutaro Shirakawa
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Keiichiro Yamane
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Masanao Toma
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Toshihiro Tamura
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Kanako Takahashi
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Haruyo Watanabe
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Yuka Yoshikawa
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Arata Tabuchi
Geriatric Medicine, Graduate School of Medicine, Kyoto University
Toru Kita
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Takeshi Kimura
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
Hisanori Horiuchi
Departments of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

Keywords: Antiplatelet therapy, Aspirin, Cardiovascular risk

JOURNAL FREE ACCESS

2010 Volume 74 Issue 6 Pages 1227-1235

DOI https://doi.org/10.1253/circj.CJ-09-0927

View "Advance Publication" version (April 10, 2010).

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Abstract

Background: Aspirin is an antiplatelet drug widely used for the prevention of cardiovascular diseases. It has been reported that some patients who exhibit a reduced antiplatelet effect of aspirin have higher cardiovascular risk. It is still controversial whether the antiplatelet effect of aspirin diminishes after a few years of treatment. This study aimed to evaluate the antiplatelet effect of aspirin and its 2-year change in Japanese patients. Methods and Results: Collagen-induced platelet-aggregability was measured at enrollment by conventional optical aggregometer in 239 patients undergoing antiplatelet therapy with aspirin alone. Among them, 167 patients were evaluated after 2 years. Whole blood aggregability based on the screen-filtration method was also evaluated. Optical aggregometer studies showed that 27% of patients were low-responders. Multivariate analyses revealed that female sex and non-use of calcium-channel blockers were associated with low responsiveness. The antiplatelet effect of aspirin did not decrease after 2 years. Similar data were obtained with the whole blood aggregometer. Conclusions: In this Japanese patient group, 27% were low-responders to aspirin, and the antiplatelet effect of aspirin did not decrease after a 2-year interval. (Circ J 2010; 74: 1227 - 1235)

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