Association Between Serum Uric Acid Levels and Cardiometabolic Risk Factors Among Japanese Junior High School Students

Minoru Hongo; Hiroya Hidaka; Shigeko Sakaguchi; Keisuke Nakanishi; Motoki Ichikawa; Naoko Hirota; Naoki Tanaka; Goro Tsuruta; Yoshikazu Yazaki; Osamu Kinoshita; Uichi Ikeda; Kenichi Koike; The Investigators of Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu

doi:10.1253/circj.CJ-09-0837

Epidemiology

Association Between Serum Uric Acid Levels and Cardiometabolic Risk Factors Among Japanese Junior High School Students

Minoru Hongo, Hiroya Hidaka, Shigeko Sakaguchi, Keisuke Nakanishi, Motoki Ichikawa, Naoko Hirota, Naoki Tanaka, Goro Tsuruta, Yoshikazu Yazaki, Osamu Kinoshita, Uichi Ikeda, Kenichi Koike, The Investigators of Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu

Author information

Minoru Hongo
Department of Cardiovascular Medicine, Shinshu University School of Health Sciences
Hiroya Hidaka
Department of Clinical Laboratory Medicine, Shinshu University School of Health Sciences
Shigeko Sakaguchi
Department of Nursing, Shinshu University School of Health Sciences
Keisuke Nakanishi
Department of Nursing, Shinshu University School of Health Sciences
Motoki Ichikawa
Department of Pediatrics, Shinshu University School of Health Sciences
Naoko Hirota
Man Healthy Faculty of Matsumoto University
Naoki Tanaka
Department of Gastroenterology, Shinshu University School of Medicine
Goro Tsuruta
Department of Pediatrics, Shinshu University School of Medicine
Yoshikazu Yazaki
Division of Cardiology, NHO Matsumoto Medical Center Matsumoto Hospital
Osamu Kinoshita
Department of Cardiovascular Medicine, Azumino Red Cross Hospital
Uichi Ikeda
Department of Cardiovascular Medicine, Shinshu University School of Medicine
Kenichi Koike
Department of Pediatrics, Shinshu University School of Medicine
The Investigators of Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu

Keywords: Cardiometabolic risk factors, Japanese junior high school students, Lifestyle-related diseases, Serum uric acid

JOURNAL FREE ACCESS

2010 Volume 74 Issue 8 Pages 1570-1577

DOI https://doi.org/10.1253/circj.CJ-09-0837

View "Advance Publication" version (June 9, 2010).

Details

Abstract

Background: The present study was designed to examine whether serum uric acid (SUA) levels were associated with cardiometabolic risk factors and to determine optimal cut-offs for SUA to identify multiple risk factors among Japanese junior high school students. Methods and Results: A total of 958 students (518 boys and 440 girls, aged 12.1-15.0 years) who were enrolled between April 2005 and June 2008 were divided into 4 groups according to SUA quartiles. Compared with the lowest quartile of SUA, prevalence of abdominal obesity, hypertension, and dyslipidemia was significantly increased in the highest quartile in boys and that of abdominal obesity was increased in the highest quartile in girls. The adjusted odds ratios (95% confidence interval) of the highest quartile of SUA for 2 or more cardiometabolic risk factors were 2.59 (1.16-5.79) for boys and 1.54 (0.43-5.56) for girls. Receiver operating characteristic curve analysis demonstrated that the most appropriate cut-offs for SUA to identify multiple cardiometabolic risk factors were 6.4 mg/dl for boys and 4.9 mg/dl for girls. Conclusions: SUA was strongly associated with the prevalence of cardiometabolic risk factors among male Japanese junior high school students. The present study may provide insights into the role of SUA in the school screening system for the development of educational programs on prevention of lifestyle-related diseases among school children. (Circ J 2010; 74: 1570 - 1577)

Corresponding author

Register with J-STAGE for free!