Cyclophosphamide Improves the Function of Post-Infarct Hearts by Reducing Old Infarct Area and Accelerating the Mobilization of CD34+ Cells

Yu Misao; Masazumi Arai; Takamasa Ohno; Hiroaki Ushikoshi; Tomoyuki Takahashi; Genzou Takemura; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara

doi:10.1253/circj.69.763

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Cyclophosphamide Improves the Function of Post-Infarct Hearts by Reducing Old Infarct Area and Accelerating the Mobilization of CD34⁺ Cells

Yu Misao, Masazumi Arai, Takamasa Ohno, Hiroaki Ushikoshi, Tomoyuki Takahashi, Genzou Takemura, Shinya Minatoguchi, Takako Fujiwara, Hisayoshi Fujiwara

Author information

Yu Misao
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Masazumi Arai
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Takamasa Ohno
Department of Oriental Medicine, Gifu University School of Medicine
Hiroaki Ushikoshi
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Tomoyuki Takahashi
Gene Therapy and Regenerative Medicine, Gifu University School of Medicine
Genzou Takemura
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Shinya Minatoguchi
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine
Takako Fujiwara
Department of Food Science, Kyoto Women's University
Hisayoshi Fujiwara
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Medicine

Keywords: CD34⁺ cell, Cyclophosphamide, 5-fluorouracil, Myocardial infarction

JOURNAL FREE ACCESS

2005 Volume 69 Issue 6 Pages 763-765

DOI https://doi.org/10.1253/circj.69.763

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Abstract

Background Myelosuppressives such as cyclophosphamide (Cy) and 5-fluorouracil (5FU), which can increase circulating CD34⁺ cells, may have a beneficial effect in the post-infarct heart. Methods and Results Twenty-four hours after 30-min ischemia - reperfusion, rabbits were intravenously treated with Cy (20 mg/kg), 5FU (15 mg/kg) or saline (S). Cy significantly improved cardiac function and remodeling and decreased the old infarct area 1 month after infarction, compared with those given S. The number of circulating CD34⁺ cells was higher and neovascularization and matrix metalloproteinase-1 was induced in the Cy group. Conclusion Cy has potential for post-infarct treatment. (Circ J 2005; 69: 763 - 765)

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