1962 年 82 巻 11 号 p. 1461-1464
Condensation of various 1-alkyl-3-aminoguanidine with 1, 5-bis(5-nitro-2-furyl)-3-pentadienone produced methyl, ethyl, propyl and dimethyl derivatives in better yields. Chemical properties of the compounds, as well as antibacterial activities against various bacteria have been studied. Especially, methyl compound, 1, 5-bis(5-nitro-2-furyl)-3-pentadienone N4-methylamidinohydrazone⋅HCl was found to show remarkable antibacterial activities against Gram positive bacteria, and also to show considerable activities against Gram negative bacteria. The compound with low toxicity was demonstrated to be absorbed into living body by oral administration and to activate urine.