YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
フラン誘導体の化学的ならびに実験化学療法的研究 (第27報)
1,5-Bis(5-nitro-2-furyl)-3-pentadienone Amidinohydrazoneの諸種アルキル誘導体の合成ならびに抗菌性について
三浦 孝次池田 政男大橋 冨次市村 圭子五十嵐 良子
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1962 年 82 巻 11 号 p. 1461-1464

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Condensation of various 1-alkyl-3-aminoguanidine with 1, 5-bis(5-nitro-2-furyl)-3-pentadienone produced methyl, ethyl, propyl and dimethyl derivatives in better yields. Chemical properties of the compounds, as well as antibacterial activities against various bacteria have been studied. Especially, methyl compound, 1, 5-bis(5-nitro-2-furyl)-3-pentadienone N4-methylamidinohydrazone⋅HCl was found to show remarkable antibacterial activities against Gram positive bacteria, and also to show considerable activities against Gram negative bacteria. The compound with low toxicity was demonstrated to be absorbed into living body by oral administration and to activate urine.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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