Tetramethylmagnolamine (-, +) (Ic), the diastereoisomer of natural tetramethylmagnolamine (+, +) (Ib) and of synthesized tetramethylmagnolamine (-, -) (Ia), was prepared by the Ullmann reaction of d-armepavine (V) and l-6′-bromolaudanosine (VI), the two 1-benzyltetrahydroisoquinoline-type bases that form its structural components. The properties of the compound so obtained are listed in Table I.