YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
海人草有効成分ならびに関連化合物の研究 第29報
Kainic Acidの分解成績体およびその関連化合物の合成 その6
三野 安栗田 章今井 欣一
著者情報
ジャーナル フリー

1955 年 75 巻 12 号 p. 1461-1466

詳細
抄録

Some time ago, Ueno and others obtained alkylpyrrolidine by the reduction of N-methyldihydrokaininediol or N-methyldihydrokainine dichloride, derived from kainic acid, and from the results of its Hofmann degradation and other reactions, assumed the structure of 1, 2-dimethyl-3-ethyl-4-isopropylpyrrolidine for the alkylpyrrolidine. This compound was prepared and its first-stage Hofmann degradation and reduction of the methine thereby obtained afforded a dihydromethine compound, possessing only one asymmetric carbon. The infrared absorption spectra of its methiodide, m.p. 186-187°, and that of dihydromethine methiodide, m.p. 207°, [α]D18: -11.5±0.5° (c=1, MeOH), derived from kainic acid, measured in chloroform, agreed in every respect. This has confirmed the alkylpyrrolidine structure and also offered one evidence for the appropriateness of the planar structure of kainic acid proposed earlier.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top