Five New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities

Sheng-Jun Dai; Gong-Fu Wang; Meng Chen; Ke Liu; Li Shen

doi:10.1248/cpb.55.1218

Regular Articles

Five New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities

Sheng-Jun Dai, Gong-Fu Wang, Meng Chen, Ke Liu, Li Shen

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Keywords: Scutellaria barbata, Labiatae, neo-clerodane diterpenoid alkaloid, scutebarbatine G, scutebarbatine H, cytotoxic activity

JOURNAL FREE ACCESS

2007 Volume 55 Issue 8 Pages 1218-1221

DOI https://doi.org/10.1248/cpb.55.1218

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Abstract

Five new neo-clerodane diterpenoid alkaloids, named scutebarbatine G (1), 6,7-di-O-nicotinoylscutebarbatine G (2), 6-O-nicotinoyl-7-O-acetylscutebarbatine G (3), scutebarbatine H (4) and 7-O-nicotinoylscutebarbatine H (5) were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1—5 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC₅₀ values in the range 3.4—8.5 μM.

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