Structures of New Cucurbitane-Type Triterpenes and Glycosides, Karavilagenins and Karavilosides, from the Dried Fruit of Momordica charantia L. in Sri Lanka

Seikou Nakamura; Toshiyuki Murakami; Junko Nakamura; Hisanori Kobayashi; Hisashi Matsuda; Masayuki Yoshikawa

doi:10.1248/cpb.54.1545

Regular Articles

Structures of New Cucurbitane-Type Triterpenes and Glycosides, Karavilagenins and Karavilosides, from the Dried Fruit of Momordica charantia L. in Sri Lanka

Seikou Nakamura, Toshiyuki Murakami, Junko Nakamura, Hisanori Kobayashi, Hisashi Matsuda, Masayuki Yoshikawa

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Keywords: Momordica charantia, karavilagenin, karaviloside, Sri Lanka, cucurbitane-type triterpene, medicinal foodstuff

JOURNAL FREE ACCESS

2006 Volume 54 Issue 11 Pages 1545-1550

DOI https://doi.org/10.1248/cpb.54.1545

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Abstract

Three new cucurbitane-type triterpene called karavilagenins A, B, and C and five new cucurbitane-type triterpene glycosides called karavilosides I, II, III, IV, and V were isolated from the dried fruit of Sri Lanka Momordica charantia L. (Cucurbitaceae) together with two known cucurbitane-type triterpenes, 19(R)-methoxy-5β,19-epoxycucurbita-6,23-dien-3β,25-diol and 5,19-epoxycucurbita-6,23-diene-3,25-diol, and nine known cucurbitane-type triterpene glycosides, goyaglycosides-b, -c, and -d, and momordicosides F₁, F₂, G, I, K, and L. The structures of karavilagenins and karavilosides were elucidated on the basis of chemical and physicochemical evidence.

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