Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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One-Pot Preparation of Chiral β-Amino Esters by Rhodium-Catalyzed Three-Components Coupling Reaction
Toshio HondaHitoshi WakabayashiKazuo Kanai
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2002 Volume 50 Issue 2 Pages 307-308

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Abstract

Chiral β-amino esters are synthesized in one-pot from three components, amines, aldehydes, and ethyl bromoacetate, under the rhodium-catalyzed Reformatsky-type reaction condition, where complete diastereoselection is achieved in the nucleophilic addition step of ethyl bromoacetate to the imines prepared in situ.

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© 2002 The Pharmaceutical Society of Japan
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