Studies on the Metabolism of Sulfadimethoxine. II. Determinations of Metabolites in Human and Rabbit Urine after Oral Administration of Sulfadimethoxine.
1967 Volume 15 Issue 9 Pages 1272-1276
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1967 Volume 15 Issue 9 Pages 1272-1276
The concentration and the amounts of sulfadimethoxine metabolites in both human and rabbit urine were determined separately using paper chromatography for 168 hours after administration. In human urine the main metabolite was sulfadimethoxine-N1-glucuronide, and more than 70% of the whole metabolites was excreted in this form. In the case of rabbit, the main metabolite was N4-acetyl sulfadimethoxine.
