Flavonoid and a Rare Benzophenone Glycoside from the Leaves of Aquilaria sinensis

Jin Qi; Jing-Jing Lu; Ji-Hua Liu; Bo-Yang Yu

doi:10.1248/cpb.57.134

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Flavonoid and a Rare Benzophenone Glycoside from the Leaves of Aquilaria sinensis

Jin Qi, Jing-Jing Lu, Ji-Hua Liu, Bo-Yang Yu

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Keywords: Aquilaria sinensis (LOUR.) GILG, Thymelaeaceae, benzophenone glucoside, flavonoid, aquilarinoside A, 7-β-D-glucoside of 5-O-methylapigenin

JOURNAL FREE ACCESS

2009 Volume 57 Issue 2 Pages 134-137

DOI https://doi.org/10.1248/cpb.57.134

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Abstract

From the leaves of Aquilaria sinensis (LOUR.) GILG, a novel benzophenone glucoside, designated as aquilarinoside A (1), and a new flavonoid, as 7-β-D-glucoside of 5-O-methylapigenin (2), along with eight known compounds (3—10) were isolated. The structures of 1 and 2 were fully characterized by spectroscopic methods (1D, 2D NMR and MS) and the relative stereochemistry was assigned based on nuclear Overhauser effect spectroscopy (NOESY) correlations and analyses of coupling constants. The new compounds showed inhibition activity against polymorphonuclear neutrophils (PMNs) respiratory burst stimulated by PMA.

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