Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease

Ji Suk Lee; Hirotsugu Miyashiro; Norio Nakamura; Masao Hattori

doi:10.1248/cpb.56.711

Notes

Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease

Ji Suk Lee, Hirotsugu Miyashiro, Norio Nakamura, Masao Hattori

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Keywords: Dryopteris crassirhizoma, human immunodeficiency virus (HIV)-1 protease, dryopteric acid A, dryopteric acid B, hopanoic acid

JOURNAL FREE ACCESS

2008 Volume 56 Issue 5 Pages 711-714

DOI https://doi.org/10.1248/cpb.56.711

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Abstract

Two new hopane type triterpenes, named dryopteric acids A (1) and B (2), were isolated from the Rhizome of Dryopteris crassirhizoma (Aspiadaceae) together with sixteen known compounds (3—18). Of isolated compounds, ursolic acid (15), and dryopteric acid A (1) and B (2) showed potent inhibitory activities against HIV-1 protease with IC₅₀ values of 8.9—44.5 μM. In addition, acetylated compounds 1 and 2 appreciably increased inhibitory activities with their IC₅₀ values of 1.7 and 10.8 μM, respectively.

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