Penicillenols from Penicillium sp. GQ-7, an Endophytic Fungus Associated with Aegiceras corniculatum

Zhen-Jian Lin; Zhen-Yu Lu; Tian-Jiao Zhu; Yu-Chun Fang; Qian-Qun Gu; Wei-Ming Zhu

doi:10.1248/cpb.56.217

Notes

Penicillenols from Penicillium sp. GQ-7, an Endophytic Fungus Associated with Aegiceras corniculatum

Zhen-Jian Lin, Zhen-Yu Lu, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Wei-Ming Zhu

Author information

Keywords: penicillenol, endophytic fungus, Penicillium, mangrove, Aegiceras corniculatum

JOURNAL FREE ACCESS

2008 Volume 56 Issue 2 Pages 217-221

DOI https://doi.org/10.1248/cpb.56.217

Details

Abstract

Six new tetramic acids derivatives, penicillenols A₁, A₂, B₁, B₂, C₁, and C₂ (1—6), together with citrinin, phenol A acid, phenol A, and dihydrocitrinin, were identified from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum. Their structures were elucidated on the basis of comprehensive spectral analysis. All the new compounds were evaluated for their cytotoxic effects on four cell lines by the MTT method. Penicillenols A₁ and B₁ showed cytotoxicities against HL-60 cell line with IC₅₀ values of 0.76 μM and 3.20 μM, respectively.

Corresponding author

Register with J-STAGE for free!