New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities

Sheng-Jun Dai; Dong-Dong Liang; Yan Ren; Ke Liu; Li Shen

doi:10.1248/cpb.56.207

Notes

New neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata with Cytotoxic Activities

Sheng-Jun Dai, Dong-Dong Liang, Yan Ren, Ke Liu, Li Shen

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Keywords: Scutellaria barbata, Labiatae, neo-clerodane diterpenoid alkaloid, scutebarbatine, cytotoxic activity

JOURNAL FREE ACCESS

2008 Volume 56 Issue 2 Pages 207-209

DOI https://doi.org/10.1248/cpb.56.207

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Abstract

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines I—L (1—4), were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were established on the basis of detailed spectral analyses. In vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC₅₀ values in the range 3.2—8.3 μM.

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