Longicalycinin A, a New Cytotoxic Cyclic Peptide from Dianthus superbus var. longicalycinus (M<small>AXIM</small>.) W<small>ILL</small>.

Pei-Wen Hsieh; Fang-Rong Chang; Ching-Chung Wu; Chien-Ming Li; Kuen-Yuh Wu; Su-Li Chen; Hsin-Fu Yen; Yang-Chang Wu

doi:10.1248/cpb.53.336

Notes

Longicalycinin A, a New Cytotoxic Cyclic Peptide from Dianthus superbus var. longicalycinus (MAXIM.) WILL.

Pei-Wen Hsieh, Fang-Rong Chang, Ching-Chung Wu, Chien-Ming Li, Kuen-Yuh Wu, Su-Li Chen, Hsin-Fu Yen, Yang-Chang Wu

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Keywords: Dianthus superbus var. longicalycinus, cyclic peptide, cytotoxicity

JOURNAL FREE ACCESS

2005 Volume 53 Issue 3 Pages 336-338

DOI https://doi.org/10.1248/cpb.53.336

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Abstract

A new cyclic peptide, longicalycinin A (1), and six known compounds, vaccaroside A, dianoside A, dianoside G, 3-(4-hydroxy-3-methoxy-phenyl)propionic acid methyl ester, p-hydroxybenzoic acid, and p-hydroxybenzaldehyde were isolated from the MeOH extract of Dianthus superbus var. longicalycinus. The amino acid sequences of 1 was elucidated as cyclo(Gly¹-Phe²-Tyr³-Pro⁴-Phe⁵-) on the basis of ESI tandem mass fragmentation analysis, chemical evidence, and extensive 2D NMR methods. Furthermore, compound 1 showed cytotoxicity to Hep G2 cancer cell line.

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