Bioactive Constituents from Chinese Natural Medicines. XIV. New Glycosides of β-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities

Toshio Morikawa; Bohang Sun; Hisashi Matsuda; Li Jun Wu; Shoichi Harima; Masayuki Yoshikawa

doi:10.1248/cpb.52.1194

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Bioactive Constituents from Chinese Natural Medicines. XIV.
New Glycosides of β-Carboline-Type Alkaloid, Neolignan, and Phenylpropanoid from Stellaria dichotoma L. var. lanceolata and Their Antiallergic Activities

Toshio Morikawa, Bohang Sun, Hisashi Matsuda, Li Jun Wu, Shoichi Harima, Masayuki Yoshikawa

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Keywords: Stellaria dichotoma L. var. lanceolata, glucodichotomine B, dichotomoside, degranulation inhibitor, antiallergy, neolignan

JOURNAL FREE ACCESS

2004 Volume 52 Issue 10 Pages 1194-1199

DOI https://doi.org/10.1248/cpb.52.1194

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Abstract

A new β-carboline-type alkaloidal glycoside, glucodichotomine B, four new neolignan glycosides, dichotomosides A, B, C, and D, and a new phenylpropanoid glycoside, dichotomoside E, were isolated from a Chinese natural medicine, the roots of Stellaria dichotoma L. var. lanceolata. The structures of the new glycosides were determined on the basis of chemical and physicochemical evidence. Among them, dichotomoside D inhibited the release of β-hexosaminidase (IC₅₀=64 μM) as well as tumor necrosis factor-α and interleukin-4 (IC₅₀=16, 34 μM) in RBL-2H3 cells. These findings suggest that dichotomoside D is more effective against the late-phase reactions in type I allergy than in the immediate phase.

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