Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Duocarmycins, Potent Antitumor Antibiotics Produced by Streptomyces sp. Structures and Chemistry
Tohru YASUZAWA, Ken'ichi MUROI, Michio ICHIMURA, Isami TAKAHASHI, Tatsuhiro OGAWA, Keiichi TAKAHASHI, Hiroshi SANO, Yutaka SAITOH
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Keywords: Streptomyces sp., antitumor antibiotic, duocarmycin, exciton chirality
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1995 Volume 43 Issue 3 Pages 378-391

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Abstract

Seven novel potent antitumor antibiotics, duocarmycins A (1), C1 (2), C2 (3), D (4), B1 (5), B2 (6) and SA (7), were isolated from three independently collected Streptomyces sp. The complete structures, including absolute stereochemistry, were determined by spectral and chemical studies of those duocarmycins and several derivatives. Duocarmycins A (1) and SA (7) possess a 1, 2, 7, 7a-tetrahydrocycloprop[1, 2-c]indol-4-one subunit, a common pharmacophore with that of CC-1065 (10) found from Streptomyces zelensis.

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© The Pharmaceutical Society of Japan
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