Application of NMR to Stereochemistry. (I). The Spatial Interaction Effect of the Hydroxyl Group to Methyl Resonance.(< ?? ?? >53)

Yutaka Kawazoe; Yoshihiro Sato; Mitsutaka Natsume; Hiroko Hasegawa; Toshihiko Okamoto; Kyosuke Tsuda

doi:10.1248/cpb.10.338

Yutaka Kawazoe, Yoshihiro Sato, Mitsutaka Natsume, Hiroko Hasegawa, Toshihiko Okamoto, Kyosuke Tsuda

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JOURNAL FREE ACCESS

1962 Volume 10 Issue 4 Pages 338-344

DOI https://doi.org/10.1248/cpb.10.338

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Abstract

The spatial vicinity of hydroxyl and methyl groups caused a remarkable downward shift for the methyl signal and this relationship was acertained by the acetylation of the hydroxyl group, causing a characteristic upward shift. This relationship might be applied to various ring systems, e.g. steroids, diterpenes, etc., predicting the spatial relation between hydroxyl and methyl groups.

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