Trypanocidal Effects of Curcumin in Vitro

Mitsuhiko NOSE; Tatsuo KOIDE; Yukio OGIHARA; Yoshisada YABU; Nobuo OHTA

doi:10.1248/bpb.21.643

Mitsuhiko NOSE, Tatsuo KOIDE, Yukio OGIHARA, Yoshisada YABU, Nobuo OHTA

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Keywords: curcumin, Trypanosoma brucei brucei (GUTat 3.1), trypanocidal activity

JOURNAL FREE ACCESS

1998 Volume 21 Issue 6 Pages 643-645

DOI https://doi.org/10.1248/bpb.21.643

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Abstract

During the course of study searching for the antiparasitic agents from natural compounds, we found that curcumin showed cytotoxicity against African trypanosomes in vitro. The LD₅₀ values of curcumin were 4.77±0.91μM for bloodstream forms and 46.52±4.94μM for procyclic forms of Trypanosoma brucei brucei (GUTat 3.1 clone).

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