Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Inhibitory Effect of Artocarpanone from Artocarpus heterophyllus on Melanin Biosynthesis
Enos Tangke ArungKuniyoshi ShimizuRyuichiro Kondo
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2006 Volume 29 Issue 9 Pages 1966-1969

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Abstract

In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.

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© 2006 The Pharmaceutical Society of Japan
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