Two New Diterpenoids from Cell Cultures of Salvia miltiorrhiza

De-Wu Zhang; Xiao Liu; Dan Xie; Ridao Chen; Xiao-Yu Tao; Jian-Hua Zou; Jungui Dai

doi:10.1248/cpb.c12-00987

Notes

Two New Diterpenoids from Cell Cultures of Salvia miltiorrhiza

De-Wu Zhang, Xiao Liu, Dan Xie, Ridao Chen, Xiao-Yu Tao, Jian-Hua Zou, Jungui Dai

Author information

De-Wu Zhang
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Xiao Liu
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Dan Xie
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Ridao Chen
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Xiao-Yu Tao
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Jian-Hua Zou
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Jungui Dai Corresponding author
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

Keywords: diterpenoid, cell culture, Salvia miltiorrhiza

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Supplementary material

2013 Volume 61 Issue 5 Pages 576-580

DOI https://doi.org/10.1248/cpb.c12-00987

Details

Abstract

A new spiroketallactone, epi-danshenspiroketallactone A (1) and a new C18-norditerpenoid, normiltioane (2) along with 21 known compounds, were isolated from cell cultures of Salvia miltiorrhiza. Their structures were elucidated on the basis of extensive spectroscopic analyses. In the in vitro assays, the compounds 9−11, 21−23 exhibited the significant antitumor activity with the IC₅₀ ranges of 1.0–8.3 µm.

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