Flavonoid Glycosides from Chromolaena odorata Leaves and Their in Vitro Cytotoxic Activity

Tran Manh Hung; To Dao Cuong; Nguyen Hai Dang; Shu Zhu; Pham Quoc Long; Katsuko Komatsu; Byung Sun Min

doi:10.1248/cpb.59.129

Notes

Flavonoid Glycosides from Chromolaena odorata Leaves and Their in Vitro Cytotoxic Activity

Tran Manh Hung, To Dao Cuong, Nguyen Hai Dang, Shu Zhu, Pham Quoc Long, Katsuko Komatsu, Byung Sun Min

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Keywords: Chromolaena odorata, Asteraceae, flavonoid glycoside, cytotoxic

JOURNAL FREE ACCESS

2011 Volume 59 Issue 1 Pages 129-131

DOI https://doi.org/10.1248/cpb.59.129

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Abstract

Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3—13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC₅₀ values of 28.2 and 11.6 μM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC₅₀ value of 10.8 μM.

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