A New Cytotoxic Polyhydroxysterol from Soft Coral Sarcophyton trocheliophorum

Hui DONG; Yu-Lin GOU; R.Manjunatha KINI; Hong-Xi XU; Shao-Xing CHEN; Serena Lay Ming TEO; Paul Pui-Hay BUT

doi:10.1248/cpb.48.1087

Hui DONG, Yu-Lin GOU, R.Manjunatha KINI, Hong-Xi XU, Shao-Xing CHEN, Serena Lay Ming TEO, Paul Pui-Hay BUT

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Keywords: Soft coral, Sarcophyton trocheliophorum, polyhydroxysterol

JOURNAL FREE ACCESS

2000 Volume 48 Issue 7 Pages 1087-1089

DOI https://doi.org/10.1248/cpb.48.1087

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Abstract

A new cytotoxic polyhydroxysterol, 23, 24, -dimethylcholest-16(17)-E-en-3β, 5α, 6β, 20(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC₅₀ values of 2.8, 4.3, and 4.9 μg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes.

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