A Novel Sesterterpenoid, Nitiol, as a potent Enhancer of IL-2 Gene Expression in a Human T Cell Line, from the Peruvian Folk Medicine"Hercumpuri" (Gentianella nitida)

Nobuo KAWAHARA; Masato NOZAWA; Atsuyo KURATA; Takashi HAKAMATSUKA; Setsuko SEKITA; Motoyoshi SATAKE

doi:10.1248/cpb.47.1344

Nobuo KAWAHARA, Masato NOZAWA, Atsuyo KURATA, Takashi HAKAMATSUKA, Setsuko SEKITA, Motoyoshi SATAKE

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Keywords: nitiol, Gentianella nitida, Hercampuri, Gentianaceae, sesterterpenoid

JOURNAL FREE ACCESS

1999 Volume 47 Issue 9 Pages 1344-1345

DOI https://doi.org/10.1248/cpb.47.1344

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Abstract

A novel sesterterpenoid designated as nitiol (1), possessing enhancement activity of IL-2 gene expression in a human T cell line, was isolated from the Peruvian folk medicine "Hercampuri" (Gentianella nitida). The structure was elucidated by extensive spectroscopic investigation.

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