Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance
Tomoko OTSUKASumie YOSHIOKAYukio ASOShigeo KOJIMA
Author information
JOURNAL FREE ACCESS

1995 Volume 43 Issue 7 Pages 1221-1223

Details
Abstract

The dynamics of water molecules associated with water-soluble polymers were studied by 17O-NMR. The observed spin-lattice relaxation time, T1(obs), of water in aqueous solutions of polyethylene glycol (PEG), poly(vinylpyrrolidone) (PVP) and gelatin at polymer concentrations below 0.12 g/g of water could be described by an isotropic two-state model with a fast exchange. The tendency for the polymers to reduce the T1(obs) of water was on the oreder of PEG<gelatin<PVP. At higher concentrations, deviations from the model were observed for PVP and gelatin. The T1(obs) of water in the PEG solution was not affected by the molecular weight of the polymer. This suggests that the microviscosity around the polymer molecules is governed by the interaction between the polymer unit and water molecules, and is not affected by the molecular weight of polymers in contrast to the "macroviscosity". The polymer-water interaction that reduced the T1(obs) of water was found to decrease with increasing temperature for all the polymers studied. The T1(obs) of water in the gelatin solution exhibited the largest temperature dependence, suggesting that changes might occur in the molecular structure of gelatin at higher temperatures.

Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top