Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury

Xiaojie Wang; Xin Zhou; Jisheng Ma; Haishan Tian; Yue Jiao; Rui Zhang; Zhifeng Huang; Jian Xiao; Binhai Zhao; Huanwen Qian; Xiaokun Li

doi:10.1248/bpb.33.971

Regular Articles

Effects of Keratinocyte Growth Factor-2 on Corneal Epithelial Wound Healing in a Rabbit Model of Carbon Dioxide Laser Injury

Xiaojie Wang, Xin Zhou, Jisheng Ma, Haishan Tian, Yue Jiao, Rui Zhang, Zhifeng Huang, Jian Xiao, Binhai Zhao, Huanwen Qian, Xiaokun Li

Author information

Xiaojie Wang
School of Public Health, Jilin University
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
Xin Zhou
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
Jisheng Ma
School of Public Health, Jilin University
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
Haishan Tian
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
Yue Jiao
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
Rui Zhang
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
Zhifeng Huang
Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical College
Jian Xiao
Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical College
Binhai Zhao
School of Public Health, Jilin University
Huanwen Qian
Institute of Radiation Medicine, The Academy of Military Medical Science
Xiaokun Li
School of Public Health, Jilin University
Biopharmaceutics and Bioreactor Research Center, Ministry of Education, Jilin Agriculture University
Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical College

Keywords: keratinocyte growth factor-2, corneal, epithelium, wound healing

JOURNAL FREE ACCESS

2010 Volume 33 Issue 6 Pages 971-976

DOI https://doi.org/10.1248/bpb.33.971

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Abstract

Keratinocyte growth factor-2 (KGF-2), also called fibroblast growth factor-10 (FGF-10), is a member of the fibroblast growth factor family. It plays a critical role in epithelial development and exerts its biological activities in a paracrine manner on the receptor FGFR2-IIIb. This study examined the function of topically applied KGF-2 in vivo on wound healing using a CO₂ laser, corneal epithelial wounded, rabbit model. Topically applied 25 μg/ml KGF-2 accelerated corneal epithelial wound healing, in contrast to the control, and reduced inflammation, stromal edema, and fibrosis. In addition, this factor also exhibited significant inhibition of corneal neovascularization. KGF-2 appears to be another important growth factor in the regulation of corneal epithelial wound healing.

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