Anti-carcinogenic Activity of the Roots of Panax notoginseng. II

Takao KONOSHIMA; Midori TAKASAKI; Harukuni TOKUDA

doi:10.1248/bpb.22.1150

Takao KONOSHIMA, Midori TAKASAKI, Harukuni TOKUDA

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Keywords: anti-carcinogenic activity, Panax notoginseng, fumonisin B1, (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1), anti-tumor-promoter, anti-tumor-initiator

JOURNAL FREE ACCESS

1999 Volume 22 Issue 10 Pages 1150-1152

DOI https://doi.org/10.1248/bpb.22.1150

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Abstract

The extract of the roots of Panax notoginseng (Araliaceae) exhibited a significant anti-tumor-promoting activity on two-stage carcinogenesis of mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA) as an initiator and a mycotoxin, fumonisin B1, as a non-12-O-tetradecanoylphorbol-13-acetate (non-TPA) type promoter. Further, the extract exhibited the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) as an intiator and TPA as a promoter.

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