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Adenoid Cystic Carcinoma of Lobar Bronchial Origin: 20-Year Experience at a Single Institution

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Pulmonary adenoid cystic carcinoma (ACC) is a rare type of lung malignancy. The prevalence of ACC of lobar bronchial origin is lower than that of other lung malignancies, and studies investigating it are lacking. This study aimed to evaluate survival of patients with ACC of the lobar bronchus after surgical resection and to explore its prognostic factors.

Methods

Between January 2000 and December 2019, 35 patients at the National Cancer Center/Cancer Hospital with a diagnosis of ACC of the lobar bronchus were included in the retrospective analysis.

Results

During a median follow-up period of 61 months (range, 10–194 months), the analysis showed a 5-year overall survival (OS) rate of 81.4%, a 5-year locoregional recurrence-free survival rate of 84.0%, and 5-year disease-free survival rate of 60.1%. The univariate analysis exclusively identified the surgical margin as a predictor of OS, and survival was significantly longer for the patients with negative surgical margins than for those with positive surgical margins (R0 vs. R1: 94.4% vs. 66.0%; p = 0.014). Adjuvant radiotherapy was administered to most of the patients with positive surgical margins, which might have contributed to prolonged OS (R0 vs. R1+RT: 94.4% vs. 66.7%, p = 0.173; R0 vs. R1+no RT: 94.4% vs. 62.5%, p = 0.007).

Conclusions

For ACC of lobar bronchial origin, complete resection is the radical treatment, and the OS rate was significantly higher for the R0 patients than for the R1 patients. Adjuvant radiotherapy for patients with R1 may prolong survival.

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Acknowledgment

Y Zhao analyzed the data and wrote the manuscript. GS He collected the data. YR Zhai, ZM Zhou, N Bi, YS Mao, ZF Xiao, SG Gao, JM Lv and Q Xue participated the research design and patient treatments. QF Feng edited and approved the manuscript. The authors wish to thank all the patients and their families who contributed to this research.

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Author notes

  1. Ying Zhao and Guosheng He contributed equally to this work.

Authors and Affiliations

  1. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Ying Zhao MD, Guosheng He MD, Yirui Zhai MD, Zongmei Zhou MD, Nan Bi MD, PhD, Zefen Xiao MD, Jima Lv MD & Qinfu Feng MD

  2. Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Yousheng Mao MD, Shugeng Gao MD & Qi Xue MD

  3. Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Yi Zhang MD

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  1. Ying Zhao MD
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  2. Guosheng He MD
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  3. Yirui Zhai MD
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  11. Qi Xue MD
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Corresponding authors

Correspondence to Yirui Zhai MD or Qinfu Feng MD.

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Cite this article

Zhao, Y., He, G., Zhai, Y. et al. Adenoid Cystic Carcinoma of Lobar Bronchial Origin: 20-Year Experience at a Single Institution. Ann Surg Oncol 29, 4408–4416 (2022). https://doi.org/10.1245/s10434-022-11590-5

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  • DOI: https://doi.org/10.1245/s10434-022-11590-5

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