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The Effect of Pancreatoduodenectomy Plus Intraperitoneal Hyperthermic Perfusion on Resectable Pancreatic Head Cancer: Cohort Study

  • Pancreatic Tumors
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Intraperitoneal hyperthermic perfusion (IPHP) has achieved positive results in treating various abdominal cancers but infrequently reported in resectable pancreatic head cancer. This study was designed to explore the safety and efficacy of pancreaticoduodenectomy plus intraperitoneal hyperthermic perfusion (PD + IPHP) in patients with pancreatic cancer.

Methods

Data of pancreatic cancer patients undergoing pancreaticoduodenectomy were retrospectively analyzed, including PD + IPHP (n = 28) and PD group (n = 29). IPHP was performed during surgery, on postoperative day (POD) 2, and POD 4 with normal saline as the perfusion solution. Complications and overall survival of these patients were observed and recorded.

Results

There was no significant difference in the incidence of major postoperative complications between PD + IPHP group and PD group. The median overall survival (OS) time of the PD + IPHP group was 19.0 months, the 1-year survival rate was 82.35%, and the 2-year survival rate was 49.41%. The median OS time of the PD group was 13.0 months, the 1-year survival rate was 51.00%, and the 2-year survival rate was 27.33% (Log-rank, P = 0.030; Breslow, P = 0.039). Cox proportional risk model showed that IPHP was an independent factor to improve survival outcomes of these patients (hazard ratio = 0.363, 95% confidence interval: 0.14–0.94; P = 0.038).

Conclusions

Intraperitoneal hyperthermic perfusion significantly improves the survival outcomes of pancreatic head cancer patients undergoing PD and does not bring extra risks of complications.

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Authors and Affiliations

  1. Hepatobiliary Surgery Department, Second Hospital of Hebei Medical University, Shijiazhuang, China

    Feng Feng MD, Xueqing Liu MD, Jianzhang Qin MD, Shubin Zhang MD, Qiusheng Li MD & Jianhua Liu MD

  2. Pediatric Surgery Department, Second Hospital of Hebei Medical University, Shijiazhuang, China

    Xuehui Cao MD

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  1. Feng Feng MD
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  2. Xuehui Cao MD
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  3. Xueqing Liu MD
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  4. Jianzhang Qin MD
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  5. Shubin Zhang MD
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  6. Qiusheng Li MD
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  7. Jianhua Liu MD
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Contributions

Feng Feng, Cao Xuehui, Liu Xueqing, Qin Jianzhang, Zhang Shubin, Li Qiusheng, and Liu Jianhua contributed to the conception and design of the research. Feng Feng proposed the design of the research, managed the draft together, and contributed equally to this study. Cao Xuehui and Liu Xueqing contributed to the acquisition the data. Qin Jianzhang, Zhang Shubin, and Li Qiusheng contributed to the analysis of the data. Liu Jianhua contributed to the acquisition, analysis, and interpretation of the data. All authors drafted the manuscript, critically revised the manuscript, agree to be fully accountable for ensuring the integrity and accuracy of the work, and read and approved the final manuscript.

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Correspondence to Jianhua Liu MD.

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All authors have nothing to disclose, including commercial relationships and conflicts of interest. No funding received in this study.

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Feng, F., Cao, X., Liu, X. et al. The Effect of Pancreatoduodenectomy Plus Intraperitoneal Hyperthermic Perfusion on Resectable Pancreatic Head Cancer: Cohort Study. Ann Surg Oncol 28, 2337–2345 (2021). https://doi.org/10.1245/s10434-020-09095-0

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  • DOI: https://doi.org/10.1245/s10434-020-09095-0

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