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Tooth Loss Predicts Long-Term Prognosis of Esophageal Cancer After Esophagectomy

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Oral health is associated with various diseases, including cancer. Tooth loss is a simple and objective index of oral health.

Objective

The purpose of this study was to investigate the association between preoperative tooth loss and esophageal cancer prognosis after esophagectomy.

Methods

This study included 191 patients who underwent esophagectomy for esophageal cancer after perioperative dental evaluation and oral care at Kobe University Hospital from April 2011 to March 2016. Patients were divided into two groups: Group A (tooth loss < 7) and Group B (tooth loss ≥ 7). Three-year overall survival (OS) and multivariate analysis were performed, along with subgroup analysis for elderly patients (age ≥ 65 years).

Results

The 3-year OS rate was 68.1% in Group A (104 patients) and 49.2% in Group B (87 patients). Group A had significantly higher OS than Group B (p = 0.002), and there were no significant differences in sex and clinical T or N stage between the two groups. However, the mean age of Group A was younger than that of Group B (64.2 vs. 68.5 years; p = 0.0002). Among elderly patients, the 3-year OS rate was 68.2% in Group A (55 patients) and 45.1% in Group B (65 patients) [p = 0.003]. Multivariate analysis that included age demonstrated that tooth loss is an independent prognostic factor (hazard ratio 1.87, 95% confidence interval 1.22–2.87), in addition to clinical T stage and preoperative serum albumin.

Conclusion

Tooth loss is an independent prognostic factor for esophageal cancer after esophagectomy.

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Funding

There were no sources of financial or material support for this study.

Author information

Authors and Affiliations

  1. Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan

    Susumu Miura MD, Tetsu Nakamura PhD, MD, Yukiko Miura MD, Gosuke Takiguchi PhD, MD, Naoki Urakawa PhD, MD, Hiroshi Hasegawa PhD, MD, Masashi Yamamoto PhD, MD, Shingo Kanaji PhD, MD, Yoshiko Matsuda PhD, MD, Kimihiro Yamashita PhD, MD, Taro Oshikiri PhD, MD & Yoshihiro Kakeji PhD, MD

  2. Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan

    Takumi Hasegawa PhD, DDS & Masaya Akashi PhD, DDS

  3. Division of Minimally Invasive Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan

    Takeru Matsuda PhD, MD

  4. Division of Community Medicine and Medical Network, Department of Social Community Medicine and Health Science, Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan

    Satoshi Suzuki PhD, MD

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  1. Susumu Miura MD
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  2. Tetsu Nakamura PhD, MD
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  15. Masaya Akashi PhD, DDS
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  16. Yoshihiro Kakeji PhD, MD
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Corresponding author

Correspondence to Susumu Miura MD.

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Disclosures

Susumu Miura, Tetsu Nakamura, Takumi Hasegawa, Yukiko Miura, Gosuke Takiguchi, Naoki Urakawa, Hiroshi Hasegawa, Masashi Yamamoto, Shingo Kanaji, Yoshiko Matsuda, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Satoshi Suzuki, Masaya Akashi, and Yoshihiro Kakeji have no commercial interests related to the subject of the study to disclose.

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Miura, S., Nakamura, T., Hasegawa, T. et al. Tooth Loss Predicts Long-Term Prognosis of Esophageal Cancer After Esophagectomy. Ann Surg Oncol 27, 683–690 (2020). https://doi.org/10.1245/s10434-019-07903-w

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  • DOI: https://doi.org/10.1245/s10434-019-07903-w

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