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High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer

  • Colorectal Cancer
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Notch1 regulates cell proliferation, development, and apoptosis. Aberrant expression of Notch1 has been discovered in many types of tumors. We examined Notch1 expression in colorectal cancer to assess its role as a prognostic indicator.

Methods

Notch1 protein expression was examined by immunohistochemistry in 223 surgically resected specimens of colorectal cancer and adjacent tissues. The relationship between various clinicopathological features and overall patient survival rate was analyzed. The association of Notch1 expression with the colorectal cancer survival rate was assessed by Kaplan–Meier and Cox proportional-hazards regression.

Results

Significantly high Notch1 expression was found in colorectal cancer cells compared with that of normal colorectal epithelial cells. Notch1 was positively correlated with depth of invasion (P = 0.005), lymph node metastases (P = 0.03), and tumor–node–metastasis (TNM) stage (P < 0.001). Consistently, the overall survival rate was significantly lower for patients with Notch1-positive than those with Notch1-negative tumors. However, no correlation between Notch1 expression and patient age, sex or tumor location was found.

Conclusion

Notch1 might serve as a novel prognostic marker that is independent of, and additive to, the TNM staging system.

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Acknowledgment

This work was supported by the National Natural Science Foundation of China (No. 30571803).

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Authors and Affiliations

  1. State Key Laboratory of Cancer Biology, Department of Gastrointestinal Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi’an, Shaanxi Province, China

    Dake Chu MD, Weizhong Wang MM, Qingchuan Zhao MD, Jipeng Li MD, Mengbin Li MD, Guanglong Dong MD, Hongwei Zhang MD & Gang Ji MD

  2. Department of Health Statistics, The Fourth Military Medical University, Xi’an, Shaanxi Province, China

    Yunming Li MD

  3. State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi’an, Shaanxi Province, China

    Yuanyuan Lu MD & Huahong Xie MD

Authors
  1. Dake Chu MD
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  2. Yunming Li MD
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  3. Weizhong Wang MM
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  4. Qingchuan Zhao MD
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  5. Jipeng Li MD
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  6. Yuanyuan Lu MD
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  7. Mengbin Li MD
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  8. Guanglong Dong MD
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  9. Hongwei Zhang MD
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  10. Huahong Xie MD
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  11. Gang Ji MD
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Corresponding author

Correspondence to Gang Ji MD.

Additional information

Dake Chu and Yunming Li contributed equally to this article.

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Chu, D., Li, Y., Wang, W. et al. High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer. Ann Surg Oncol 17, 1337–1342 (2010). https://doi.org/10.1245/s10434-009-0893-7

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  • DOI: https://doi.org/10.1245/s10434-009-0893-7

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