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REFERENCES
Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ. Cancer Statistics, 2003. CA Cancer J Clin 2003; 53: 5–26.
Elisaf M, Roukos DH, Briasoulis E, Michos KM, Agnantis NJ, Kappas AM. Comparing recent advances in gastric and breast cancer. Gastric Breast Cancer 2002; 1: 59–64.
Morrow M, Strom EA, Bassett LW, et al. Standard for breast conservation therapy in the management of invasive breast carcinoma. CA Cancer J Clin 2002; 52: 277–300.
Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002; 347: 1233–41.
Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002; 347: 1227–32.
Morrow M. Rational local therapy for breast cancer. N Engl J Med 2002; 347: 1270–1.
van Dongen JA, Voogd AC, Fentiman IS, et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000; 92: 1143–50.
Freedman GM, Hanlon AL, Fowble BL, Anderson PR, Nikolaou N. Recursive partitioning identifies patients at high and low risk for ipsilateral tumor recurrence after breast-conserving surgery and radiation. J Clin Oncol 2002; 20: 4015–21.
Neuschatz AC, DiPetrillo T, Safaii H, et al. Long-term follow-up of a prospective policy of margin-directed radiation dose escalation in breast-conserving therapy. Cancer 2003; 97: 30–9.
Roukos DH, Agnantis NJ, Batsis H, Paraskevaidis E, Kappas AM. Breast-conserving surgery and risk of positive margins in breast cancer. Gastric Breast Cancer 2003;2:15–9. Available at: http://www.gastriccancer.net/Margins_abs.asp.
Smitt MC, Nowels KW, Zdeblich MJ, et al. The important of the lumpectomy surgical margin status in long-term results of breast conservation. Cancer 1995; 76: 259–67.
Park C, Mitsumori M, Recht A, et al. The relationship between pathologic margin status and outcome after breast-conserving therapy. Int J Radiat Oncol Biol Phys 1998; 42: 125.
Cowen D, Houvenaeghel G, Bardou V-J, et al. Local and distant failures after limited surgery with positive margins and radiotherapy for node-negative breast cancer. Int J Radiat Oncol Biol Phys 2000; 47: 305–12.
Padera TP, Kadambi A, di Tomaso E, et al. Lymphatic metastasis in the absence of functional intratumour lymphatics. Science 2002; 296: 1883–6.
Peterson ME, Schultz DJ, Reynolds C, et al. Outcomes in breast cancer patients relative to margin status after treatment with breast-conserving surgery and radiation therapy: the University of Pennsylvania experience. Int J Radiat Oncol Biol Phys 1999; 43: 1029–35.
National Surgical Adjuvant Breast and Bowel Project. NSABP Progress Report 2001. Pittsburgh: National Surgical Adjuvant Breast and Bowel Project, 2002:84, 94, 140.
Fisher B, Dignam J, Bryant J, et al. Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. J Natl Cancer Inst 1996; 88: 1529–42.
Dalberg K, Johansson H, Johansson U, et al. A randomized trial of long-term adjuvant tamoxifen plus postoperative radiation therapy versus radiation therapy for patients with early-stage breast carcinoma treated with breast-conserving surgery. Cancer 1998; 82: 2204—11.
Smith TE, Lee D, Turner BC, Carter B, Haffty BG. True recurrence vs. new primary ipsilateral breast tumor relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management. Int J Radiat Oncol Biol Phys 2000; 481: 281–9.
Bartelink H, Horiot JC, Poortmans P, et al. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med 2001; 345: 1378–87.
Black N. Evidence-based surgery: a passing fad? World J Surg 1999; 23: 789–93.
Early Breast Cancer Trialists’ Collaborative Group. Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 2000; 355: 1757–70.
Kurtz JM, Jacquemier J, Amalric R, et al. Why are local recurrences after breast-conserving therapy more frequent in younger patients? J Clin Oncol 1990; 8: 591–8.
Orel SG, Schnall MD, Powell CM, et al. Staging of suspected breast cancer: effect of MR imaging and MR-guided biopsy. Radiology 1995; 196: 115–22.
van de Vijver MJ, He YD, van’t Veer LJ, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347: 1999–2009.
Keyomarsi K, Tucker SL, Buchholz TA, et al. Cyclin E and survival in patients with breast cancer. N Engl J Med 2002; 347: 1566–75.
Roukos DH, Agnantis NJ. Gene-expression profile: the future in the outcome prediction and treatment of breast cancer. Gastric Brteast Cancer 2003;2:5–8. Available at: http://www.gastriccancer.net/ Gene-Expression_abs.asp.
Agnantis NJ, Roukos DH. Cyclin E: a new biologic prognostic marker for breast cancer? Gastric Breast Cancer 2003;2:9–11. Available at: http://www.gastriccancer.net/Cyclin_abs.asp.
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Roukos, D.H., Kappas, A.M. & Agnantis, N.J. Perspectives and Risks of Breast-Conservation Therapy for Breast Cancer. Ann Surg Oncol 10, 718–721 (2003). https://doi.org/10.1245/ASO.2003.05.925
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DOI: https://doi.org/10.1245/ASO.2003.05.925