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Palliative Management of Peritoneal Metastases

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Despite significant recent advances in the management of peritoneal carcinomatosis, this diagnosis still is accompanied frequently by a grim survival prognosis, often measured in weeks to months. The poor prognosis also is accompanied often by complications and symptoms that have a dramatic impact on quality of life and are challenging to the managing health care provider and devastating to loved ones caring for the person who is suffering. Consequently, management of carcinomatosis often revolves around palliation of symptoms such as bowel obstruction, nausea, pain, fatigue, and cachexia as well as emotional and existential concerns. This article reviews several palliative treatment options for some of the more common symptoms and complications associated with advanced, incurable peritoneal carcinomatosis. Although readers should recognize that carcinomatosis is no longer an imminent death sentence, providers caring for patients with peritoneal carcinomatosis also must be well-versed in the palliative management of this condition and recognize the utility of early palliative care referral in this setting.

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References

  1. Paul Olson TJ, Pinkerton C, Brasel KJ, Schwarze ML. Palliative surgery for malignant bowel obstruction from carcinomatosis: a systematic review. JAMA Surg. 2014;149:383–92.

    Article  PubMed  PubMed Central  Google Scholar 

  2. S1316, Surgery or nonsurgical management in treating patients with intraabdominal cancer and bowel obstruction. 2017. Retrieved 24 Sept 2017, from https://clinicaltrials.gov/ct2/show/NCT02270450?term=swog+malignant+bowel+obstruction&rank=1.

  3. White JV, Guenter P, Jensen G, et al. Consensus statement: academy of nutrition and dietetics and American Society for parenteral and enteral nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). JPEN J Parenter Enteral Nutr. 2012;36:275–83.

    Article  PubMed  Google Scholar 

  4. Mosler P, Mergener KD, Brandabur JJ, Schembre DB, Kozarek RA. Palliation of gastric outlet obstruction and proximal small bowel obstruction with self-expandable metal stents: a single-center series. J Clin Gastroenterol. 2005;39:124–8.

    PubMed  Google Scholar 

  5. Holt AP, Patel M, Ahmed MM. Palliation of patients with malignant gastroduodenal obstruction with self-expanding metallic stents: the treatment of choice? Gastrointest Endosc. 2004;60:1010–7.

    Article  PubMed  Google Scholar 

  6. Ly J, O’Grady G, Mittal A, Plank L, Windsor JA. A systematic review of methods to palliate malignant gastric outlet obstruction. Surg Endosc. 2010. https://doi.org/10.1007/s00464-009-0577-1.

    Article  PubMed  Google Scholar 

  7. Zheng B, Wang X, Ma B, Tian J, Jiang L, Yang K. Endoscopic stenting versus gastrojejunostomy for palliation of malignant gastric outlet obstruction. Dig Endosc. 2012. https://doi.org/10.1111/j.1443-1661.2011.01186.x.

    Article  Google Scholar 

  8. Yoon JY, Jung YS, Hong SP, Kim TI, Kim WH, Cheon JH. Clinical outcomes and risk factors for technical and clinical failures of self-expandable metal stent insertion for malignant colorectal obstruction. Gastrointest Endosc. 2011;74:858–68.

    Article  PubMed  Google Scholar 

  9. Sagar J. Colorectal stents for the management of malignant colonic obstructions. Cochrane Database Syst Rev. 2011. https://doi.org/10.1002/14651858.cd007378.

    Article  PubMed  Google Scholar 

  10. Kim JH, Ku YS, Jeon TJ, et al. The efficacy of self-expanding metal stents for malignant colorectal obstruction by noncolonic malignancy with peritoneal carcinomatosis. Dis Colon Rectum. 2013;56:1228–32.

    Article  PubMed  Google Scholar 

  11. Caceres A, Zhou Q, Iasonos A, Gerdes H, Chi DS, Barakat RR. Colorectal stents for palliation of large-bowel obstructions in recurrent gynecologic cancer: an updated series. Gynecol Oncol. 2008;108:482–5.

    Article  PubMed  Google Scholar 

  12. Pothuri B, Montemarano M, Gerardi M, et al. Percutaneous endoscopic gastrostomy tube placement in patients with malignant bowel obstruction due to ovarian carcinoma. Gynecol Oncol. 2005;96:330–4.

    Article  PubMed  Google Scholar 

  13. Ryan JM, Hahn PF, Mueller PR. Performing radiologic gastrostomy or gastrojejunostomy in patients with malignant ascites. AJR Am J Roentgenol. 1998;171:1003–6.

    Article  PubMed  CAS  Google Scholar 

  14. Shaw C, Bassett RL, Fox PS, et al. Palliative venting gastrostomy in patients with malignant bowel obstruction and ascites. Ann Surg Oncol. 2013;20:497–505.

    Article  PubMed  Google Scholar 

  15. Laval G, Marcelin-Benazech B, Guirimand F, et al. Recommendations for bowel obstruction with peritoneal carcinomatosis. J Pain Symptom Manage. 2014;48:75–91.

    Article  PubMed  Google Scholar 

  16. Feuer DJ, Broadley KE. Corticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. Cochrane Database Syst Rev. 2000. https://doi.org/10.1002/14651858.cd001219.

    Article  Google Scholar 

  17. Laval G, Rousselot H, Toussaint-Martel S, et al. SALTO: a randomized, multicenter study assessing octreotide LAR in inoperable bowel obstruction. Bull Cancer. 2012;99:E1–9.

    PubMed  Google Scholar 

  18. Mariani P, Blumberg J, Landau A, et al. Symptomatic treatment with lanreotide microparticles in inoperable bowel obstruction resulting from peritoneal carcinomatosis: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol. 2012;30:4337–43.

    Article  PubMed  CAS  Google Scholar 

  19. Narayanan P, Nobbenhuis M, Reynolds KM, Sahdev A, Reznek RH, Rockall AG. Fistulas in malignant gynecologic disease: etiology, imaging, and management. Radiographics. 2009;29:1073–83.

    Article  PubMed  Google Scholar 

  20. Fleming ND, Alvarez-Secord A, Von Gruenigen V, Miller MJ, Abernethy AP. Indwelling catheters for the management of refractory malignant ascites: a systematic literature overview and retrospective chart review. J Pain Symptom Manage. 2009;38:341–9.

    Article  PubMed  Google Scholar 

  21. Garofalo A, Valle M, Garcia J, Sugarbaker PH. Laparoscopic intraperitoneal hyperthermic chemotherapy for palliation of debilitating malignant ascites. Eur J Surg Oncol. 2006;32:682–5.

    Article  PubMed  CAS  Google Scholar 

  22. Facchiano E, Scaringi S, Kianmanesh R, et al. Laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of malignant ascites secondary to unresectable peritoneal carcinomatosis from advanced gastric cancer. Eur J Surg Oncol. 2008;34:154–8.

    Article  PubMed  CAS  Google Scholar 

  23. Patriti A, Cavazzoni E, Graziosi L, et al. Successful palliation of malignant ascites from peritoneal mesothelioma by laparoscopic intraperitoneal hyperthermic chemotherapy. Surg Laparosc Endosc Percutan Tech. 2008;18:426–8.

    Article  PubMed  Google Scholar 

  24. Valle M, Van der Speeten K, Garofalo A. Laparoscopic hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) in the management of refractory malignant ascites: a multi-institutional retrospective analysis in 52 patients. J Surg Oncol. 2009;100:331–4.

    Article  PubMed  CAS  Google Scholar 

  25. Ba MC, Cui SZ, Lin SQ, et al. Chemotherapy with laparoscope-assisted continuous circulatory hyperthermic intraperitoneal perfusion for malignant ascites. World J Gastroenterol. 2010;16:1901–7.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  26. Antos F, Dytrych P, Vitek P, Ryska O, Marvan J, Serclovla Z. Malignant ascites–optional management using hyperthermic peroperative chemotherapy (HIPEC). Rozhl Chir. 2010;89:237–41.

    PubMed  CAS  Google Scholar 

  27. Ba MC, Long H, Cui SZ, et al. Multivariate comparison of B-ultrasound-guided and laparoscopic continuous circulatory hyperthermic intraperitoneal perfusion chemotherapy for malignant ascites. Surg Endosc. 2013;27:2735–43.

    Article  PubMed  Google Scholar 

  28. Randle RW, Swett KR, Swords DS, et al. Efficacy of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in the management of malignant ascites. Ann Surg Oncol. 2014;21:1474–9.

    Article  PubMed  Google Scholar 

  29. Sangisetty SL, Miner TJ. Malignant ascites: a review of prognostic factors, pathophysiology and therapeutic measures. World J Gastrointest Surg. 2012;4:87–95.

    Article  PubMed  PubMed Central  Google Scholar 

  30. World Health Organization. Cancer pain relief: with a guide to opioid availability, 2nd ed. Geneva: World Health Organization; 1996. p. 12–5.

  31. Cauley CE, Panizales MT, Reznor G, et al. Outcomes after emergency abdominal surgery in patients with advanced cancer: opportunities to reduce complications and improve palliative care. J Trauma Acute Care Surg.2015;79:399–406.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Pameijer CR, Mahvi DM, Stewart JA, Weber SM. Bowel obstruction in patients with metastatic cancer: does intervention influence outcome? Int J Gastrointest Cancer. 2005;35:127–33.

    Article  PubMed  Google Scholar 

  33. Smith TJ, Temin S, Alesi ER, et al. American society of clinical oncology provisional clinical opinion: the integration of palliative care into standard oncology care. J Clin Oncol. 2012;30:880–7.

    Article  PubMed  Google Scholar 

  34. www.nccn.org/professionals/physician_gls/pdf/palliativecare.

  35. Temel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2012;363:733–42.

    Article  Google Scholar 

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Correspondence to Laura A. Lambert.

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Lambert, L.A., Wiseman, J. Palliative Management of Peritoneal Metastases. Ann Surg Oncol 25, 2165–2171 (2018). https://doi.org/10.1245/s10434-018-6335-7

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  • DOI: https://doi.org/10.1245/s10434-018-6335-7

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