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Development and Prospect of Theranostic Medical Isotopes and Radiopharmaceuticals in China
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摘要: 核医学诊疗一体化是将放射性核素显像与内放射治疗相结合，从而实现疾病的可视化诊断和精准治疗。目前，核医学诊疗一体化已在分化型甲状腺癌、嗜铬细胞瘤、恶性肿瘤骨转移、神经内分泌肿瘤、前列腺癌中发挥重要作用。我国医用放射性核素及放射性药物短缺，严重依赖进口，存在“卡脖子”问题，应加强诊疗一体化医用放射性核素及放射性药物的自主生产与创新研发力度，以促进核医学诊疗一体化更好地服务我国临床实践。Abstract: Theranostics in nuclear medicine is the combination of radionuclide imaging and internal radiotherapy, so as to realize the visualized diagnosis and precise treatment of diseases. At present, theranostics of nuclear medicine has played an important role in differentiated thyroid carcinoma, pheochromocytoma, bone metastases, neuroendocrine tumors and prostate cancer. China's medical radionuclides and radionuclide medicines are in short supply and heavily dependent on imports, so there is a "bottleneck" problem. It is necessary to strengthen the independent production, innovation and research of medical radionuclides and radiopharmaceutics of theranostics, so as to promote theranostics of nuclear medicine to better serve China's clinical practice.
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Key words:
- theranostics /
- nuclear medicine /
- radionuclide /
- thyroid carcinoma /
- neuroendocrine neoplasms
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诊断性放射性药物 治疗性放射性药物 临床诊断与治疗病种 Na123I、Na124I Na131I 分化型甲状腺癌 123I-MIBG、124I-MIBG 131I-MIBG 嗜铬细胞瘤 99mTc-MDP、18F-NaF 89SrCl2、223RaCl2 恶性肿瘤骨转移 68Ga-DOTATATE 177Lu-DOTATATE 神经内分泌肿瘤 68Ga-PSMA 177Lu-PSMA 前列腺癌 
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表 2 具有应用前景的诊疗一体化核素
诊断性放射性核素 配对的治疗性放射性核素 123I/124I 131I 68Ga 177Lu 68Ga 225Ac 64Gu 67Gu 44Sc 47Sc 152Tb 161Tb 86Y 90Y 99mTc 188Re
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