Objective To investigate the efficacy of transnasal and small intestinal decompression tube in the treatment of intestinal obstruction after radical operation of colorectal cancer.Methods This is a retrospective analysis. From January 2016 to March 2020, clinical data of patients with intestinal obstruction after radical operations of colorectal cancer were collected and treated by transnasal small intestine decompression tube.Results In 49 cases of intestinal obstruction after radical operation of colorectal cancer, there are 25 cases of effective treatment (51.0%); in 28 cases of colon cancer, there are 14 cases were assessed effectively (50.0%); in 21 cases of rectal cancer, there are 11 cases were assessed effectively (52.4%); in 38 cases of no stoma was performed in these cased, 18 cases of effective (47.4%); in 11 cases who performed stoma, 7 cases were assessed effectively (63.6%); in 28 cases who didn’t occurred abdominal metastasis, 18 cases were assessed effectively (64.3%); in 21 cases with abdominal metastasis, 7 cases were assessed effectively (33.3%).Conclusion Transnasal small intestinal decompression tube is an effective treatment for intestinal obstruction after radical operation of colorectal cancer, especially for patients without abdominal metastasis, which has the value for popularization.