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Abstract

Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.

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Author notes

Department of Oncology (M.Y.A., S.A.G.);Department of Surgery, Division of Thoracic Surgery (S.C.Y.);Department of Pathology (P.C.B.); andDepartment of Medicine, Division of Pulmonary and Critical Care (J.B.O.), Johns Hopkins Medical Institutions, Baltimore, MD 21231;University of Maryland School of Medicine, Baltimore, MD 21201 (B.W.); andWashington University School of Medicine, St. Louis, MO 63110 (A.P.); USA

© 2004 by the Society for Neuro-Oncology
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