杨晖，伍锋，吴宗贵，周小晓，樊民

引用本文： 杨晖，伍锋，吴宗贵，周小晓，樊民.活心丸（浓缩丸）治疗阳虚血瘀型经皮冠状动脉介入术后心绞痛的临床研究[J].中西医结合心脑血管病杂志,2023,21(5):775-779

摘要： 目的：观察温阳化瘀代表方活心丸（浓缩丸）治疗阳虚血瘀型经皮冠状动脉介入术（PCI）后心绞痛的临床疗效。方法：选取2019年1月－2021年12月上海中医药大学附属岳阳中西医结合医院收治的阳虚血瘀型PCI术后心绞痛病人126例，6例脱失，最终纳入120例，随机分为试验组和对照组，每组60例。在规范化西药治疗基础上，试验组给予活心丸（浓缩丸），每次2粒，每日3次，对照组给予活心丸（浓缩丸）安慰剂，每次2粒，每日3次，两组疗程均为12周。观察两组治疗前后中医证候积分、西雅图心绞痛量表评分、心绞痛评分、硝酸甘油减停率、炎性因子水平。结果：试验组治疗后中医证候积分低于对照组，西雅图心绞痛量表评分高于对照组，差异均有统计学意义（P＜0.01）；试验组硝酸甘油停减率优于对照组（P＜0.05）。试验组治疗后血清炎性因子白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平低于对照组，差异有统计学意义（P＜0.01），两组治疗后超敏C反应蛋白（hs-CRP）比较差异无统计学意义（P＞0.05）。结论：活心丸（浓缩丸）能有效改善病人阳虚血瘀型PCI术后心绞痛的临床症状，改善中医证候积分，减少硝酸甘油使用量，降低血清炎性因子水平。

关键词： 经皮冠状动脉介入术；心绞痛；阳虚血瘀型；活心丸（浓缩丸）；中医证候积分；炎性因子

课题： 国家自然科学基金项目（No.82074266）；上海市科学技术委员会科技创新项目（No.21JC1405300）

YANG Hui, WU Feng, WU Zonggui, ZHOU Xiaoxiao, FAN Min

Abstract Objective:To study the clinical efficacy of Huoxin Pill(Concentrated Pill) on angina pectoris after percutaneous coronary intervention(PCI) of Yang-deficiency and blood-stagnation type.Methods:A total of 126 patients with angina pectoris after PCI of Yang-deficiency and blood-stasis type were selected,6 cases dropped out,120 cases were finally included and randomly divided into the experimental group(60 cases) and control group(60 cases).The patients in experimental group were given Huoxin Pill(concentrated pill) plus standardized western medicine treatment,and the patients in control group were given Huoxin Pill(concentrated pill) placebo plus standardized western medicine treatment. The course of treatment in both groups was 12 weeks.TCM symptom scores,Seattle Angina Questionnaire score,angina score,nitroglycerin reduction rate,and levels of inflammatory factors were observed.Results:After treatment,the TCM syndrome score of experimental group was lower than that of control group,and the Seattle Angina Scale score was higher than that of control group,and the differences were statistically significant(P＜0.01).The discontinuation rate of nitroglycerin in experimental group was better than that in control group(P＜0.05).After treatment,the levels of serum inflammatory factors interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α) in experimental group were lower than those in control group,and the differences were statistically significant(P＜0.01). There was no significant difference in high-sensitivity C-reactive protein(hs-CRP) between the two groups after treatment(P＞0.05).Conclusion:Huoxin Pill(concentrated Pill) can effectively improve the clinical symptoms of angina pectoris after PCI,improve TCM syndrome score,reduce the use of nitroglycerin,and the level of serum inflammatory factors.

Keywords percutaneous coronary intervention; angina pectoris; Yang deficiency and blood stasis; Huoxin Pill(Concentrated Pill); traditional Chinese medicine syndrome score; inflammatory factor

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