庞家栋，沈智杰，陈铁军，郭蔚

引用本文： 庞家栋，沈智杰，陈铁军，郭蔚.丹参酮ⅡA磺酸钠注射液干预非ST段抬高型急性冠脉综合征血瘀证的临床研究[J].中西医结合心脑血管病杂志,2019,17(5):723-726

摘要： 目的探讨丹参酮ⅡA磺酸钠注射液干预非ST段抬高型急性冠脉综合征（NSTEACS）病人经皮冠状动脉介入术（PCI）围术期的临床疗效。方法选取在上海中医药大学附属曙光医院住院并接受PCI术的NSTEACS病人62例，随机分为对照组和治疗组，每组31例。对照组给予西药标准治疗；治疗组在西药标准治疗的基础上，自PCI术前2 d至PCI术后3 d使用丹参酮ⅡA磺酸钠注射液干预，比较干预前后两组病人血瘀证积分、氧化应激指标［超敏C反应蛋白（hsCRP）、超氧化物歧化酶（SOD）、一氧化氮（NO）］。结果治疗组显效率为38.71%，总有效率为87.10%；对照组显效率为16.13%，总有效率为61.29%，两组显效率、总有效率比较差异有统计学意义（P＜0.05）。治疗组PCI术后血瘀证积分、hsCRP、SOD、NO均明显优于对照组，差异有统计学意义（P＜0.05）。结论 在NSTEACS病人PCI围术期采用丹参酮ⅡA磺酸钠干预后，可明显改善血瘀证积分、中医临床证候，并能降低炎症指标，改善氧化应激，保护血管内皮功能。

关键词： 非ST段抬高型急性冠脉综合征；丹参酮ⅡA磺酸钠注射液；血瘀证；炎症因子；氧化应激

作者简介： 1.上海中医药大学附属曙光医院（上海201203）；2.同济大学附属上海东方医院 郭蔚，Email: danny9187@163.com

课题： 国家青年科学基金项目（No.81403137）

PANG Jiadong,SHEN Zhijie,CHEN Tiejun,GUO Wei

Abstract ObjectiveTo investigate the clinical efficacy of tanshinone ⅡA sodium sulfonate injection in perioperative period of patients with nonSTsegment elevation acute coronary syndrome (NSTEACS).MethodsSixtytwo patients with NSTEACS underwent percutaneous coronary intervention (PCI) in our hospital were enrolled,and randomly divided into two groups:control group(n＝31)treated with routine treatment,and treatment group (n＝31)treated with tanshinone ⅡA sodium sulfonate injection in the basis of routine treatment from 2 days before PCI to 3 days after PCI.The scores of blood stasis syndrome and levels of oxidative stress indexes［hypersensitive Creactive protein(hsCRP),superoxide dismutase(SOD),nitric oxide(NO)］were compared between the two groups before and after intervention.ResultsThe effective rate was 38.71% in treatment group,and 16.13% in control group.The total effective rate was 87.10% in treatment group,and 61.29% in control group.There were significant differences in the effective rate and total effective rate between two groups(P＜0.05).There were significant differences in the scores of blood stasis syndrome,and levels of hsCRP,SOD,and NO between two groups after PCI(P＜0.05).ConclusionTanshinone ⅡA sodium sulfonate injection can significantly improve blood stasis syndrome,reduce inflammation indicators,improve oxidative stress,and protect vascular endothelial function in patients with NSTEACS.

Keywords nonSTsegment elevation acute coronary syndrome;tanshinone ⅡA sodium sulfonate injection;blood stasis syndrome;inflammatory factor;oxidative stress

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