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Association of Silver Nanoparticles and Curcumin Solid Dispersion: Antimicrobial and Antioxidant Properties

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Abstract

The last century, more precisely after 1945, was marked by major advances in the treatment of infectious diseases which promoted a decrease in mortality and morbidity. Despite these advances, currently the development of antimicrobial resistance has been growing drastically and therefore there is a pressing need to search for new compounds. Silver nanoparticles (AgNps) have been demonstrating good antimicrobial activity against different bacteria, viruses, and fungi. Curcumin (CUR) extracted from rhizomes of Curcuma longa has a variety of applications including antiinflammatory, antioxidant, and antibacterial agent. The association between silver nanoparticles and curcumin in a formulation can be a good alternative to control infectious diseases due the antimicrobial properties of both compounds. The objective of this work was to develop a formulation composed of a thermoresponsive gel—with antimicrobial and antioxidant properties due to the association of AgNps with PVP and PVA polymers. After AgNp synthesis, these were incorporated together with the previously prepared CUR/P407 (1:2) solid dispersion (SD) into a polymer dispersion of 20% P407 (thermosensitive gel). Our results showed that the association between the AgNps with CUR SD demonstrated good antioxidant activity as compared to the standard compound. Measures of MIC showed more efficacy against Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) than for Gram-positive bacteria (Staphylococcus aureus). This association enhances antimicrobial activity against E. coli and P aeruginosa and added antioxidant value in formulations.

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Acknowledgements

Capes (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), FAPESP (Fundação de Amparo da Pesquisa do Estado de São Paulo), and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) for financial support.

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Authors and Affiliations

  1. LaBNUS—Biomaterials and Nanotechnology Laboratory, University of Sorocaba, Sorocaba, SP, Brazil

    Thais Francine Alves, Marco V. Chaud & Carolina Alves dos Santos

  2. Department of Technology and Environmental Process, University of Sorocaba UNISO, Sorocaba, SP, Brazil

    Marco V. Chaud, Denise Grotto & Angela Faustino Jozala

  3. Nanobiotechnology Lab., Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, 444 602, India

    Raksha Pandit & Mahendra Rai

  4. Universidade de Sorocaba (UNISO), Cidade Universitária Prof. Aldo Vannucchi, Rod. Raposo Tavares km 92.5, Sorocaba/SP, São Paulo, CEP 18023-000, Brazil

    Carolina Alves dos Santos

Authors
  1. Thais Francine Alves
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  2. Marco V. Chaud
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  3. Denise Grotto
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  4. Angela Faustino Jozala
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  5. Raksha Pandit
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  6. Mahendra Rai
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  7. Carolina Alves dos Santos
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Correspondence to Carolina Alves dos Santos.

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Alves, T.F., Chaud, M.V., Grotto, D. et al. Association of Silver Nanoparticles and Curcumin Solid Dispersion: Antimicrobial and Antioxidant Properties. AAPS PharmSciTech 19, 225–231 (2018). https://doi.org/10.1208/s12249-017-0832-z

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  • DOI: https://doi.org/10.1208/s12249-017-0832-z

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