Skip to main content
SpringerLink
Log in

Note on the Measurement of Bulk Density and Tapped Density of Powders According to the European Pharmacopeia

  • Brief/Technical Note
  • Published:
AAPS PharmSciTech Aims and scope Submit manuscript

Abstract

The apparent volume and compressibility index of commonly used excipients were evaluated according to European Pharmacopeia monograph (seventh edition) in order to study the influence of the procedure conditions. The results suggested that the leveling of the powder inside the cylinder ought to be avoided.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

REFERENCES

  1. Schussele A, Bauer-Brandl A. Note on the measurement of flowability according to the European Pharmacopoeia. Int J Pharm. 2003;257(1–2):301–4.

    Article  PubMed  CAS  Google Scholar 

  2. Carr RL. Evaluating the flow properties of solids. Chem Eng. 1965;72:163–8.

    CAS  Google Scholar 

  3. Hausner H. Friction conditions in a mass of metal powder. Int J Powder Metall. 1967;3:7–13.

    Google Scholar 

  4. Abdullah EC, Geldart D. The use of bulk density measurements as flowability indicators. Powder Technol. 1999;102(2):151–65.

    Article  CAS  Google Scholar 

Download references

ACKNOWLEDGMENTS

We would like to thank the generous gift of the excipients to FMC International, Ireland, JRS Pharma LP, USA, and Meggle PHARMA, Germany.

Author information

Authors and Affiliations

  1. Research Centre for Pharmaceutical Sciences, Department of Drug Sciences, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal

    J. P. Sousa e Silva, P. Costa & J. M. Sousa Lobo

  2. Department of Health Sciences, Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Ijuí, Brazil

    D. Splendor

  3. Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    I. M. B. Gonçalves

Authors
  1. J. P. Sousa e Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Splendor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. M. B. Gonçalves
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. M. Sousa Lobo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. P. Sousa e Silva.

Rights and permissions

Reprints and permissions

About this article

Cite this article

e Silva, J.P.S., Splendor, D., Gonçalves, I.M.B. et al. Note on the Measurement of Bulk Density and Tapped Density of Powders According to the European Pharmacopeia. AAPS PharmSciTech 14, 1098–1100 (2013). https://doi.org/10.1208/s12249-013-9994-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1208/s12249-013-9994-5

Key words

Search

Navigation