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Electric Field-Controlled Benzoic Acid and Sulphanilamide Delivery from Poly(Vinyl Alcohol) Hydrogel

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Abstract

The controlled release of benzoic acid (3.31 Å) and sulphanilamide (3.47 Å) from poly(vinyl alcohol), PVA, hydrogels fabricated by solution casting at various cross-linking ratios, were investigated. The PVA hydrogels were characterized in terms of the degree of swelling, the molecular weight between cross-links, and the mesh size. The drug release experiment was carried out using a modified Franz diffusion cell, at a pH value of 5.5 and at temperature of 37°C. The amount of drug release and the diffusion coefficients of the drugs from the PVA hydrogels increased with decreasing cross-linking ratio, as a larger mesh size was obtained with lower cross-linking ratios. With the application of an electric field, the amount of drug release and the diffusion coefficient increased monotonically with increasing electric field strength, since the resultant electrostatic force drove the ionic drugs from the PVA matrix. The drug size, matrix pore size, electrode polarity, and applied electric field were shown to be influential controlling factors for the drug release rate.

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REFERENCES

  1. Rhodes III WE. Iontophoretic drug delivery: new advantages revitalize an established technology. Drug Deliv Technol. 2002;2:34–7.

    Google Scholar 

  2. Kalia YN, Naik A, Garrison J, Guy RH. Iontophoretic drug delivery. Adv Drug Deliv. 2004;56:619–58.

    Article  CAS  Google Scholar 

  3. Nho YC, Park SE, Kim HI. Oral delivery of insulin using pH-sensitive hydrogels based on polyvinyl alcohol grafted with acrylic acid/methacrylic acid by radiation. Nucl Instrum Meth Phys Res Sect B. 2005;236:283–8.

    Article  CAS  Google Scholar 

  4. Serra L, Domenechc J, Peppas NA. Drug transport mechanisms and release kinetics from molecularly designed poly (acrylic acid-g-ethylene glycol) hydrogels. Biomaterials. 2006;27:5440–51.

    Article  PubMed  CAS  Google Scholar 

  5. Zalfen AM, Nizet D, Jerome C, Jerome R, Frankenne F, Foidart JM, et al. Controlled release of drugs from multi-component biomaterials. Acta Biomater. 2008;4:1778–96.

    Article  Google Scholar 

  6. Langer R, Peppas N. Chemical and physical structure of polymers as carriers for controlled release of bioactive agents: a review. J Macromol Sci Rev Macromol Chem Phys. 1983;23:61–126.

    Article  Google Scholar 

  7. Kim SJ, Park SJ, Lee SM, Lee YM, Kim HC, Kim SI. Electroactive characteristics of interpenetrating polymer network hydrogels composed of poly(vinyl alcohol) and poly(N-isopropylacrylamide). J Appl Polym Sci. 2002;89:890–4.

    Article  Google Scholar 

  8. Li JK, Wang N, Wu XS. Poly (vinyl alcohol) nanoparticles prepared by freezing–thawing process for protein/peptide drug delivery. J Control Release. 1998;56:117–26.

    Article  PubMed  CAS  Google Scholar 

  9. He C, Kim SW, Lee DS. In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery. J Control Release. 2008;127:189–207.

    Article  PubMed  CAS  Google Scholar 

  10. Peppas NA, Wright SL. Drug diffusion and binding in ionizable interpenetrating networks from poly(vinyl alcohol) and poly(acrylic acid). Eur J Pharm Biopharm. 1998;46:15–29.

    Article  PubMed  CAS  Google Scholar 

  11. Juntanon K, Niamlang S, Rujiravanit R, Sirivat A. Electrically controlled release of sulfosalicylic acid from crosslinked poly(vinyl alcohol) hydrogel. Int J Pharm. 2008;356:1–11.

    Article  PubMed  CAS  Google Scholar 

  12. Paradee N, Sirivat A, Niamlang S, Prissanaroon-Ouajai W. Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel. J Mater Sci Mater Med. 2012;23:999–1010.

    Article  PubMed  CAS  Google Scholar 

  13. Hickey AS, Peppas NA. Solute diffusion in poly(vinyl alcohol)/(polyacrylic acid) composite membranes prepared by freezing/thawing techniques. Polymer. 1997;38:5931–6.

    Article  CAS  Google Scholar 

  14. Peppas NA, Wright SL. Solute Diffusion in poly(vinyl alcohol)/poly(acrylic acid) interpenetrating networks. Macromolecules. 1996;29:8798–804.

    Article  CAS  Google Scholar 

  15. Venkatesh S, Hodgin L, Hanson P, Suryanarayanan R. In vitro release kinetics of salicylic acid from hydrogel patch formulations. J Control Release. 1992;18:13–8.

    Article  CAS  Google Scholar 

  16. Higuchi WI. Analysis of data on the medicament release from ointment. J Pharm Sci. 1962;51:802–4.

    Article  PubMed  CAS  Google Scholar 

  17. Uslu I, Celikkan H, Atakol O, Aksu ML. Preparation of PVA/chitosan doped with boron composite Fibers and their characterization Hacettepe. J Biol Chem. 2008;36(2):117–22.

    Google Scholar 

  18. Qiu Y, Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev. 2001;53:321–39.

    Article  PubMed  CAS  Google Scholar 

  19. Pradhan R, Budhathoki U, Thapa P. Formulation of once a day controlled release tablet of indomethancin based on HPMC-Mannitol. KUSET. 2008;1:55–67.

    Google Scholar 

  20. Mahmoodi M, Khosroshahi ME, Atyabi F. Laser thrombolysis and in vitro study of tPA release encapsulated by chitosan coated PLGA nanoparticles for AMI. Int J Biol Biomed Eng. 2010;4:35–42.

    Google Scholar 

  21. Dai WS, Barbari TA. Hydrogel membranes with mesh size asymmetry based on the gradient crosslinking of poly(vinyl alcohol). J Membr Sci. 1999;156:67–79.

    Article  CAS  Google Scholar 

  22. Kantaria S, Rees GD, Lawrence MJ. Gelatin stabilized microemultion-based organogels: rheology and application in iontophoretic transdermal drug delivery. J Control Release. 1999;60:355–65.

    Article  PubMed  CAS  Google Scholar 

  23. Massoumi B, Entezmi A. Controlled release of sulfosalicylic acid during electrochemical switching of conducting polymer bilayer. Eur Polym J. 2001;37:1015–20.

    Article  CAS  Google Scholar 

  24. Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. J Pharm Biopharm. 2000;50:27–46.

    Article  CAS  Google Scholar 

  25. A-sasutjarit R, Sirivat A, Vayumhasuwan P. Viscoelastic properties of carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases. Pharm Res. 2005;22:2134–40.

    Article  PubMed  CAS  Google Scholar 

  26. Niamlang S, Sirivat A. Electrically controlled release of salicylic acid from poly(p-phenylene vinylene)/polyacrylamide hydrogels. Int J Pharm. 2010;356:1–11.

    Google Scholar 

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ACKNOWLEDGMENTS

The authors would like to acknowledge the Conductive and Electroactive Polymers Research Unit of Chulalongkorn University, the Center of Petroleum Petrochemical and Advanced Materials, the Thailand Research Fund (BRG), and the Royal Thai Government for their financial supports.

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Authors and Affiliations

  1. Conductive and Electroactive Polymers Research Unit, The Petroleum and Petrochemical College, Chulalongkorn University, Bangkok, 10330, Thailand

    Jarinya Sittiwong, Nophawan Paradee & Anuvat Sirivat

  2. Department of Materials and Metallurgical Engineering, Faculty of Engineering, Rajamangala University of Technology Thanyaburi, Klong 6, Thanyaburi, Pathumthani, 12110, Thailand

    Sumonman Niamlang

Authors
  1. Jarinya Sittiwong
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  2. Sumonman Niamlang
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  3. Nophawan Paradee
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  4. Anuvat Sirivat
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Correspondence to Anuvat Sirivat.

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Sittiwong, J., Niamlang, S., Paradee, N. et al. Electric Field-Controlled Benzoic Acid and Sulphanilamide Delivery from Poly(Vinyl Alcohol) Hydrogel. AAPS PharmSciTech 13, 1407–1415 (2012). https://doi.org/10.1208/s12249-012-9869-1

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  • DOI: https://doi.org/10.1208/s12249-012-9869-1

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