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Effects of physical properties for starch acetate powders on tableting

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Abstract

The aim of the study was to investigate particle and powder properties of various starch acetate powders, to study the effect of these properties on direct compression characteristics, and to evaluate the modification opportunity of physical properties for starch acetate powders by using various drying methods. At the end of the production phase of starch acetate, the slurry of starch acetate was dried using various techniques. Particle, powder, and tableting properties of end products were investigated. Particle size, circularity, surface texture, water content and specific surface area varied according to the particular drying method of choice. However, all powders were freely flowing. Bulk and tapped densities of powders varied in the range of 0.29 to 0.44 g/cm3 and 0.39 to 0.56 g/cm3, respectively. Compaction characteristics revealed that all powders were easily deformed under compression, having yield pressure values of less than 66 MPa according to Heckel analysis. All powders possessed a significant interparticulate bond-forming capacity during compaction. The tensile strength values of tablets varied between 10 and 18 MPa. In conclusion, physical properties of starch acetate could be affected by various drying techniques. A large specific surface area and water content above 4% were favorable properties by direct compression, especially for small, irregular, and rough particles.

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Authors and Affiliations

  1. Department of Pharmaceutics, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland

    Ossi Korhonen, Seppo Pohja, Eero Suihko, Mika Vidgren, Petteri Paronen & Jarkko Ketolainen

  2. VTT Chemical Technology, Materials Technology, PO Box 21, FIN-05210, Rajamäki, Finland

    Soili Peltonen

Authors
  1. Ossi Korhonen
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  2. Seppo Pohja
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  3. Soili Peltonen
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  4. Eero Suihko
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  5. Mika Vidgren
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  6. Petteri Paronen
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  7. Jarkko Ketolainen
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Correspondence to Ossi Korhonen.

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Korhonen, O., Pohja, S., Peltonen, S. et al. Effects of physical properties for starch acetate powders on tableting. AAPS PharmSciTech 3, 34 (2002). https://doi.org/10.1208/pt030434

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  • DOI: https://doi.org/10.1208/pt030434

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