Abstract
We performed a comparative study of 24hr hGH secretion vs. stimulation tests in 48 pts. vided into 5 groups: GR 1 - organic CNS disorder, no hGH; GR 2 - partial GH def., low hGH; GR 3 - short stature, normal hGH; GR 4 idiopathic high hGH; OR 5 - Laron type dwarfism, very high hGR.
(*A-IC is the average of 48 samples drawn every 30 min. with a Cormed continuous withdrawal pump.) By all parameters the groups differ significantly. Differences in pulse amplitude between groups 1 & 2 are more distinguishable. Various patterns of rhythmicity were observed by cosinor and power spectra analysis. The present study indicates that the analysis of the hGH 24hr secretory pattern is a more sensitive discriminator of the GH-RH-hGH axis than provocative tests.
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Keret, R., Bauman, B., Wasserman, M. et al. ADVANTAGES OF THE hGH 24hr SECRETORY PATTERN IN DISTINGUISHING GROWTH DISORDERS. Pediatr Res 23, 124 (1988). https://doi.org/10.1203/00006450-198801000-00138
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DOI: https://doi.org/10.1203/00006450-198801000-00138