Abstract
GH secretion was measured by 30 mins. sampling over 24 hrs (using a Cormed pump) in 3 tall girls (aged 12, 14 & 16 yrs), belonging to a family of tall stature (4 of 7 sibs & parents were above 90th centile). In all the sibs an iv TRH bolus (200 mcg) caused a rise of plasma GH from 3.±1.5 to 58.±67. ng/ml (m±SD). The 24-hrs GH secretion pattern was compared to 2 matched control subjects:
Fasting serum IGF-1 levels were elevated in 2 girls aged 11 (37 nM/1) and 15 yrs (48 nM/l), and within the normal range in the rest of the sibs (16-43 nM/l), and in the parents (16.5 & 24.2 nM/l), with a significant correlation to their basal GH levels (r=.85, p< .02).
In conclusion, the pattern of GH secretion in several members of a family with tall stature was reported. In all the siblings an abnormal GH response to TRH and in 3 tested an increased daily output of GH was found.
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Dickerman, Z., Kalijman, M., Keret, R. et al. 24-HOUR GH SECRETION PATTERN IN FAMILIAL TALL STATURE. Pediatr Res 20, 1196 (1986). https://doi.org/10.1203/00006450-198611000-00135
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DOI: https://doi.org/10.1203/00006450-198611000-00135