Abstract
Speculation: The relative absence of apparent brain volume regulation in response to acute water loads in the newborn in comparison to the adult is due to mechanical factors, namely the more compliant newborn skull. The more compliant skull allows a greater increase in intracranial volume before intracranial pressure values are reached that are critical for pressure-dependent brain volume regulatory processes, e.g. bulk flow loss of brain ecf and CSF via arachnoid villi.
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Nattie, E., Edwards, W. Brain Water and ion Content During Progressive Water Loading in the Newborn Puppy. Pediatr Res 17, 606–608 (1983). https://doi.org/10.1203/00006450-198307000-00018
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DOI: https://doi.org/10.1203/00006450-198307000-00018